Globally, the number of new HIV infections in 2010 was 21% down on that peak, seen in 1997, according to UNAids 2011 report.
The organisation says both falls have been fuelled by a major expansion in access to treatment.
This latest analysis says the number of people living with HIV has reached a record 34 million.
Sub-Saharan Africa has seen the most dramatic improvement, with a 20% rise in people undergoing treatment between 2009 and 2010.
UNAids estimates 700,000 deaths were averted last year because of better access to treatment.
The UN agency said: “The number of new HIV infections is 30-50% lower now than it would have been in the absence of universal access to treatment for eligible people living with HIV.”If you would like to submit a guest post and be heard on the leading medical blog read our sumbission policy.