palms soles rashIn USMLE exams you will probably come  across ~3-7 questions on palms and soles rash. This list of diseases causing this rash is very high yield to memorize for USMLE.

Here is the list:

  • Meningococcemia
  • Keratoderma blenorrhagica (Reiter’s syndrome)
  • Typhus
  • Acral lentiginous melanoma
  • Hand, Foot, and Mouth Disease
  • Mercury poisoning in children
  • Bacterial endocarditis
  • Tylosis
  • Rocky Mountain Spotted Fever
  • Graft Versus Host Disease rash.
  • Kawasaki, Measles, or Toxic Shock Syndrome
  • Steven Johnson syndrome
  • Secondary and Congenital Syphilis with it’s characteristic Copper colored rash.