What are endogenous antimicrobial peptides (AMP)?

  • AMP are protein molecules that are found in all organisms having potent anti-microbial activity.
  • They are most abundantly found in keratinocytes, sebocytes and sweat glands.
  • There are two types of AMPs. 1- Cathelicidins and 2- Defensins
  • The only known human cathelicidin is LL-37(Schauber and Gallo 2008).
  • These molecules are responsible for stopping antimicrobial invasion of skin, recruit immune cells for providing adaptive immune response and innate immune response.
  • They induce apoptosis in athogenic and cancerous cells.

A good question would be even though in psoriasis barrier function is disrupted still we don’t see so many bacterial infections in psoriatic skin. Why?

References:

Schauber and Gallo 2008. Antimicrobial peptides and the skin immune defense system. Journal of Allergy and Clinical Immunology 122(2), pp. 261–266. doi: 10.1016/j.jaci.2008.03.027.

 

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