- AMP are protein molecules that are found in all organisms having potent anti-microbial activity.
- They are most abundantly found in keratinocytes, sebocytes and sweat glands.
- There are two types of AMPs. 1- Cathelicidins and 2- Defensins
- The only known human cathelicidin is LL-37(Schauber and Gallo 2008).
- These molecules are responsible for stopping antimicrobial invasion of skin, recruit immune cells for providing adaptive immune response and innate immune response.
- They induce apoptosis in athogenic and cancerous cells.
A good question would be even though in psoriasis barrier function is disrupted still we don’t see so many bacterial infections in psoriatic skin. Why?
Schauber and Gallo 2008. Antimicrobial peptides and the skin immune defense system. Journal of Allergy and Clinical Immunology 122(2), pp. 261–266. doi: 10.1016/j.jaci.2008.03.027.